Prosess DNA damage pathway

BH3 domain-only proteins

Noxa and Puma (and perhaps Bid),

Bax,………………….--> p53 can activate mitochondria. Upregulation of Apaf will promote Caspase-9 activation, while upregulation of Htr/Omi helps to abrogate IAP function downstream of the mitochondria.

 doelwit genen:

1. regulatie         : Mdm2 onstaat àproteosoom

2. Cel cyclus arrest: e.g. p21Cip = Cdk4/CyclinD inhibitor

3. apoptose: Bax, Noxa, Puma, Bid?, Apaf, reaper (Drosophila = Diablo/Smac homoloog), HTR/Omi, p53AIP, CD95, Trail-R2